BaAMPs collect antimicrobial peptides specifically tested against microbial biofilms in an exhaustive and detailed manner.
BaAMPs provides information on:
Sequences and physiochemical properties of AMPs testedagainst microbial biofilms
Evaluation of peptide antibiofilm activities in terms of active AMPconcentrations and corresponding biofilm reduction
Experimental conditions used to evaluate theactivity
Methods used to evaluate the reduction of biofilm
Microbial species/strains towardswhich activity was evaluated
Biofilms are sessile communities of microorganisms adhering tovarious biotic or abiotic surfaces and embedded in a self-produced extracellular matrix. Biofilmformation occurs basically through four typical stages: adhesion of planktonic cells to a surface, growthof the attached cells with production of the extracellular polymeric matrix, biofilm maturation, anddispersion of single cells and/or clusters of cells from the biofilm, with subsequent colonization of otherlocations. As the formation of the biofilm proceeds, microbial cells become more firmly attached to thesubstrate and more protected from the action of antimicrobials and host immune defenses.
Antimicrobial peptides (AMPs) are a diverse group of molecules that represent one of the most ancient components of the immune system, found in virtually all forms of life. Hailed as a promising solution to the growing crisis of antibiotic resistance, these natural compounds are now at the forefront of biofilm research. Many AMPs have demonstrated a powerful dual ability: they can prevent bacteria from forming biofilms in the first place and can also eradicate mature, established biofilms, making them a vital tool in the development of new therapies for persistent infections.